Sunday, May 17, 2020
Pain And Fatigue Of The Elderly - 1048 Words
Pain and Fatigue in the Elderly Ingrid Medina Nebraska Methodist College Pain and Fatigue in the Elderly The elderly population increasing, there is more of an incidence in chronic conditions, such as cancer. Cancer is the second top cause for morbidity and mortality in the older adult population that is older than 65 years of age (nearly 71 percent of all deaths) (Erturk et al., 2015). Cancer affects both different processes of the body and psychological process. One process includes pain perception. Researchers estimate that as many as 90 percent of cancer patients experience pain and 50 percent do not receive enough pain management (as citied as Erturk el al., 2015). There is often a stigma for older adults that pain and fatigue are a common process of aging; therefore, elderly have misconceptions of medications (e.g. opioids) and attitudes about pain and will often tolerate pain (Erturk et al., 2015, p. 167). One of my previous elderly patients was admitted for abdominal pain (hepatomegaly). I chose this research article because one of my priorities for her care was to managing her pain in relation to her abdominal pain and physical activity throughout the shift. The purpose of the research article was to ââ¬Å"evaluate the pain and fatigue levels of elderly cancer patients and to examine whether pain is an independent variable in fatigue developmentâ⬠(Erturk et al., 2015, p. 167). The study design is a descriptive and cross sectional study from November 21,Show MoreRelatedSigns And Symptoms Of Depression Essay1040 Words à |à 5 Pagesavailable and your capaacity to reason is impaired. Fatigue According to the National Institutes for Health (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225130/), unexplained fatigue is one of the most common symptoms cited when patients seek help. This fatigue is profound, impacting concentation, physical health and emotional resilience. You may sleep but wake tired and you are bored but haven t the will for action. Science has found that fatigue and depression feed each other. Unfortunately, manyRead MoreChickenpox Essay887 Words à |à 4 Pageshowever, symptoms of rash are not apparent until almost two weeks after exposure to the virus due to virus incubation period. The red spots appear on the face, chest, and back first and then spread all around the body. Other symptoms may include fever, fatigue, headache, and loss of appetite.5 Although it is a mild infection that doesnââ¬â¢t cause serious effects on healthy children, it can cause severe complications when acquired by adults,2,6 individuals with weakened immune system, or pregnan t women6. InRead MoreSymptoms And Treatment Of Ill And Weak Individuals998 Words à |à 4 PagesHidden Illness Society in general feels pity or concern for the ill and weak individuals. It may be because they have been raised to believe this is an appropriate response to their pain. On the other hand some may just feel compassion for the person, but they believe it does not benefit the individual to pity them. It is normal for people to feel an emotional response to other individualââ¬â¢s situations. However, illnesses are normally associated with the conditions that are visible to the naked eyeRead MoreThe Development Of Musculoskeletal Disorders Essay1644 Words à |à 7 PagesAs people age, they begin to see changes in their body. One major problem that elderly people begin to have is the development of musculoskeletal disorders. These disorders are extremely common and the risk of developing one increases as a person ages. Musculoskeletal disorders consist of minor disabilities. They include a variety of conditions that affect the muscles, bones, and joints. As people age, they begin to have fragile bones, less cartilage resilience, a decreased amount of ligament elasticityRead MoreIntroduction. Geriatric Depression Is The Most Common Serious1365 Words à |à 6 PagesIntroduction Geriatric depression is the most common serious disease in elderly people, especially with older hospital patients, yet is often difficult to diagnose and many primary care clinicians fail to recognize depression cases. This research examines the causes, symptoms, and treatments of depression in the elderly. The causes of depression in the elderly are varies depending on their medication, their mental state, and other factors such as physiological and biochemical change. According toRead MoreEssay on Understanding Dementia in the Elderly532 Words à |à 3 PagesDelirium, Depression, and Dementia are some of the most common psychological diagnoses in the elderly today. The three Dââ¬â¢s are difficult to differentiate between in older adults because they overlap with each other and can all exist in the same patient at once. Delirium, Dementia, and Depression all affect the elderlyââ¬â¢s quality of life and often increase the risks for one another (Downing, Caprio Lyness, 2013). For the purpose of this paper I will be focusing primarily on the diagnosis of DementiaRead MoreRheumatoid Arthritis : An Autoimmune Etiology1521 Words à |à 7 Pagesfollowing ways: swelling and damage of the joints (synovitis); bone destruction; formation of autoantibodies, like rheumatoid factor (RF) and anti-citrullinated peptide (ACPA); persistent functional decline; vasculitis; fatigue; increased disability; dysphasia; stiffness and pain, mostly in the hands and wrist; functional limitations and physical disabilities; systemic manifestations that may include renal, eye , and vascular issues; cardiovascular disease and myocardial infarctions; ultimately leadingRead MoreAquatic Therapy : A Therapy Essay1325 Words à |à 6 Pagescan be used for many different types of illness, diseases, syndromes, disorders, pain, and musculoskeletal problems. Especially, osteoporosis, osteoarthritis, fibromyalgia, low back pain. Aquatic therapy continues to be improving and is becoming more popular. It can also help normal/healthy humans live a healthier life. So Iââ¬â¢m going to be discussing the different types of illness, diseases, syndromes, disorders, pain, and musculoskeletal problems and explain if aquatic therapy help manage their symptomsRead MoreCompassion Fatigue Resulting From Disenfranchised Grief1683 Words à |à 7 Pages Compassion Fatigue Resulting from Disenfranchised Grief in Health Care Professionals Kathryn Brown Denver School of Nursing SOC 220, Cohort A Compassion Fatigue Resulting from Disenfranchised Grief in Health Care Professionals This paper explores the emotional differences that people in the health care profession experience when it comes to the death of a patient. It defines the bereavement role, the four tasks of mourning, disenfranchised grief, compassion fatigue and how ambiguity and a lackRead MoreTotal Knee Replacement1425 Words à |à 6 Pagesdizziness, peripheral edema, and flushing. Immediate-acting forms of nifedipine can cause reflex tachycardia. To avoid rebound hypotension, the drug should be discontinued gradually. In rare cases, nifedipine may cause a paradoxical increase in anginal pain, possibly related to hypotension or heart failure.Contraindications: the only contraindication is prior hypersensitivity to nifedipine.INTERACTIONSDrug- Drug: when given concurrently, other antihypertensives have additive effects with nifedipine on
Wednesday, May 6, 2020
Essay about edgar allan poe - 557 Words
Edgar Allan Poe Edgar Allan Poe was born on January 19, 1809 in Boston, Massachusetts. He was the son of two poor touring actors, Elizabeth Arnold Poe and David Poe Jr. The Poes traveled around to many different theaters, playing many different roles. While his mother was a well-known actor, his father was not, and was usually drunk during performances. David Poe abandoned his family when Edgar was about two and the rest of the Poe family left for Richmond, Virginia. Edgarââ¬â¢s mother died of tuberculosis there in Richmond. Edgar was only three at the time but apparently he remembered the traumatizing event later in life. After his motherââ¬â¢s death, John and Frances Allan took Edgar in. John Allan was a wealthy merchant. Allan changed Edgarâ⬠¦show more contentâ⬠¦Poeââ¬â¢s literary career had now begun, but did not take off. Poe was able to publish some of his works but was still quite poor. Poe had a turn of good fortune when, in 1835, he became the editor of the Southern Literary Messenger. Through his position as editor, Poe published many of his poems. In 1836, Poe married his cousin, Virginia Clemm, who was thirteen years old. Fired from the Messenger for drinking, Poe moved from city to city with Virginia looking for a job. He found one at Burtonââ¬â¢s Gentlemanââ¬â¢s Magazine, where he became the co-editor. Poeââ¬â¢s career hit its peak with The Raven, which turned him into a local celebrity over night in New York. The publishing of the poem gave Poe enough money to live comfortably on his own for the very first time in his life. In 1847, Poeââ¬â¢s wife died at the same age (24) and of the same disease (tuberculosis) as his mother. Poe was unable to write anything for at least half a year while he was in severe depression over the loss of his wife. The first piece he wrote after her death was Ulalume, which was a reflection of Poeââ¬â¢s state of mind at the time of Virginiaââ¬â¢s death. So distraught by his wifeââ¬â¢s death, Poe began drinking heavily. He was found in the streets of Baltimore, semi-conscious wearing clothes that did not belong to him and he was drunk. He was brought to a local hospital. His last words were said to be ââ¬Å"Lord help my poor soulâ⬠. Poe died October 7, 1849 at the age ofShow MoreRelatedEdgar Allan Poe721 Words à |à 3 PagesEdgar Allan Poe Edgar Allen Poe, born is 1809, was an American short story writer, poet, and critic. He is commonly know as the father of detective stories. His most well know work of art is his poem The Raven (Werlock). Although Poe had a short lived career, his literature continues to influence many writers in the United States and Europe. He worked with many genres such as: gothic tale, science fiction, occult fantasies, and satire. While many critics consider his works of literature as grotesqueRead MoreEdgar Allan Poe792 Words à |à 4 Pagesauthor, Edgar Allan Poe, on Sunday October 7, 1849. In Massachusetts on the 19th day of January in the year 1809, Edgar Poe was born to actress Elizabeth Arnold Hopkins Poe and actor David Poe Junior, making him an older brother to Rosalie Poe, and a younger one to William Henry Leonard Poe. Poe may, perchance, have been named after a character in the play that his parents were performing that year. He was never formally adopted, however, Edgar Poe was r enamed Edgar Allan Poe when the John Allan familyRead MoreEdgar Allan Poe1245 Words à |à 5 Pagesbe discussing about my poet Edgar Allan Poe. Poe had written numerous of poems and stories but the one I chose was ââ¬Å"Annabel Leeâ⬠. This poem was written in 1849 which was a long time ago. Even though this poem is centuries old, it is still a well known poem. This whole project includes a biography, literary movement, and a explication about the poem. The biography includes where Poe grew up and how his lifestyle were. Through research and sources, I found out that Poe lived a hard life. He was inRead MoreThe Rise Of Poe By Edgar Allan Poe1635 Words à |à 7 PagesThe Rise of Poe The words people use and how they use them holds so much power within themselves. It seems that, people are always searching for the right words to express their true emotions towards a certain subject. Artists and authors manage to make a living off of knowing how to use the right words to reach through to their platform. Though within his time, Edgar Allan Poe did not have an established platform and was seen as estranged; he still dabbled as an author and has made many famous shortRead More Edgar Allan Poe Essay515 Words à |à 3 Pages Edgar Allan Poe nbsp;nbsp;nbsp;nbsp;nbsp;Edgar Allan Poe, the first master of the short story, had written many short stories from mysteries to morbidity. Edgar was born on January 19,1809 in Boston, Massachussettes. Edgars Parents, David and Eliza, were both in the acting business. Poe also had a sister, who is rarely spoken of. When Edgar was young his father fleed from the family, leaving Edgar, his mother, and sister alone. At the age of two Edgars mother died of tuberculosis. Edgar wasRead MoreDeath By Edgar Allan Poe975 Words à |à 4 Pagesabout the topic, and the fear of not knowing this leads it to be a taboo subject in many discussions. Edgar Allan Poe defied this sense of taboo and wrote many works centering on the topic of death. It is Edgar Allan Poeââ¬â¢s discussion of death in his works that reveals the innate human perversion of the discussion of death. The reason for his discussion of death may find roots in his personal life. Poe was born into a traveling family in 1809 and had two other siblings. His parents tragically lost theirRead MoreThe Biography Of Edgar Allan Poe841 Words à |à 4 PagesThe Biography of Edgar Allan Poe ââ¬Å"Lord, help my poor soulâ⬠, the last and final words of the amazing writer, Edgar Allan Poe, before his sudden death in 1849. Edgar Allan Poe wrote dark and treacherous stories and poems that often lead to the questioning of his mental state. Poe lived a rather difficult life in which writing was his escape. He at one time was in so much debt that he could have never payed it back even if his career took off. No one ever knew what had happened to Poe, only that heRead More Edgar Allan Poe Essay1589 Words à |à 7 Pages Edgar Allen Poe Edgar Allan Poe Edgar Allen Poeââ¬â¢s contributions to American literature have become increasingly more prominent as the years have passed. As short fiction has become a more accepted genre in literary circles, Poeââ¬â¢s theories are studied with more passion. Although he lived a rather melancholy life, Poe did experience moments of joy, and desired to capture the beauty through poetic form. Indeed, what he left behind for the literary world was his gifted genus, revealed throughRead MoreEdgar Allan Poe Essay1575 Words à |à 7 PagesEdgar Allan Poe Edgar Allan Poe was a bizarre and often scary writer. People throughout history have often wondered why his writings were so fantastically different and unusual. They were not the result of a diseased mind, as some think. Rather they came from a tense and miserable life. Edgar Allan Poe was not a happy man. He was a victim of fate from the moment he was born to his death only forty years later. He died alone and unappreciated. It is quite obvious that his life affected hisRead MoreEdgar Allan Poe Essay812 Words à |à 4 PagesEdgar Allan Poe Edgar Allan Poe was one of Americas famous poets, fiction short-story writers, and literary critics. He is known as the first master of short story form especially in tales of horror, and mystery. The work he produced was considered to be some of the most influential literary criticism of his time. His poems made him one of the most famous figures in American literary history. His influence on literature is seen in all literature books in schools everywhere. Some of his famous
Tuesday, May 5, 2020
Multimedia Design & Web Page
Question: Discuss about the Webpage and Multimedia Design? Answer: Introduction This website is about me and my career history. This website has below pages: Home About Education Career Gallery Blog Contact FAQ SiteMAP Compatibility, Website is compitable with below Browsers: Internet Explorer Chorme Mozila Screenshots Home Page: Put Screenshot after made changes to current page with your data About: Put Screenshot after made changes to current page with your data Education: Put Screenshot after made changes to current page with your data Career: Put Screenshot after made changes to current page with your data Gallery: Put Screenshot after made changes to current page with your data Blog: Put Screenshot after made changes to current page with your data Contact: Put Screenshot after made changes to current page with your data FAQ: Put Screenshot after made changes to current page with your data Sitemap: Put Screenshot after made changes to current page with your data
Sunday, April 19, 2020
The Girl With the Green Suede Sneakers free essay sample
The first person I noticed was the girl with the green suede sneakers. She was just alittle different. Standing there alone, she had scraggly brown hair pulled tautin a florescent pink tie that clashed miserably with her misshapen green- andblue-striped jacket. With stretched-out cotton blue pants that failed to extendpast her ankles and glowing orange scrunch socks, she stood in silence, cleaningher frosted eyeglasses with her shirt. It was a cold day in November andthe start of the winter track season. I stood with my friends, carefullysurveying the scene of prospective new teammates. It was all too obvious that agood number were not athletic, and we knew they would be gone within days. It wasthe same way every year. Yet, there was something about the girl with the greensuede sneakers, as I listened to my friends gossip about her. Haveyou guys seen that girl over there? I heard someone say, pointing in herdirection. We will write a custom essay sample on The Girl With the Green Suede Sneakers or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Does she honestly think that outfit looks good?another giggled. Glancing at my new shiny spandex and brilliant white shoes, Iadmired my running apparel. Surely I must fit in. No one would dare talk aboutme. So the girl with the green suede sneakers stood alone, and I joined thegiggles of my friends. I too began to wonder about what she was wearing, as ifher clothes determined her personality. Sticking out like a sore thumb, sheshivered in the wind as we began our workout. Following us to the startingline, the girl with the green suede sneakers looked confused. Whatis a 400-meter repeat? she asked with a slight accent unfamiliar to me. Ipondered her origins for a moment, then quickly forgot about it as one of myteammates sarcastically yelled the answer. I rolled my eyes in disbelief alongwith the others. Quickly, though, I remembered that just last year Iwould have asked the same question. I wondered if they had been that sarcasticwith me. No, that wasnt possible, I looked like a runner. So I continued,showing off my speed and joking with my friends as the girl with the green suedeshoes fell farther behind. Clearly out of shape, she huffed and puffed across thefinish line as my friends stood, barely out of breath, and ready to push on.Walking to the bleachers where I had left my water, I took a sip and relaxedwhile my friends started to do cool down. Deciding to wait and catch mybreath, I started running by myself. Moments later, I heard the loud slap oftired feet close behind me. Thinking it was one of my friends, I turned around,only to see the girl with the green sneakers looking confused again. What is cool down? she asked, and I explained, beginning towonder how anyone could possibly be so clueless about what we were doing. Runningin silence for a few steps, we rounded the track again as I gazed up at thesky. Isnt the sunset beautiful? she remarked, her accent moreobvious this time. Indeed it was, a swirl of pastel oranges and pinksintermingled with stripes of pale purple. I just love sunsets, especiallythose at the lakes by my home, she added. Beginning to wonder about heraccent, I asked, Are you from this country? No, I amfrom Germany, Im an exchange student this year. For the next lap, Ifound myself asking her about everything: her favorite foods, how she likedAmerica, how to say different words in German. I was so engulfed in ourconversation that even after we finished our run, we walked into the building,still talking, as I grew more fascinated with her culture andexperiences. When we got to the locker room, I said, Nice meetingyou, and continued on my way. Then I paused. Had I just been having thatawesome conversation with the girl with the green suede sneakers? Was she thesame awkward character whose mismatched clothes and slightly unkempt hair hadattracted the attention of me and my friends? Disappointed in myself, Irealized how judgmental I had been. Her personality was not represented by theclothes she wore. I had made a great new friend from another country whosestories were fascinating. How could I have been so wrapped up in appearance? Ihad always prided myself on being accepting of other cultures. Narrow-minded, Iwas caught in what I thought would be acceptable to others and had almost missedout on making a new friend. After all, wasnt she more than a pair of green suedesneakers?
Saturday, March 14, 2020
Air Canada Takes Off with Maintenix Essays
Air Canada Takes Off with Maintenix Essays Air Canada Takes Off with Maintenix Paper Air Canada Takes Off with Maintenix Paper Air Canada Takes off with Maintenix Read the Interactive Session: Technology, and then discuss the following questions: 1. What problems does Air Canada hope that Maintenix will solve? 2. How does Maintenix improve operational efficiency and decision-making? 3. Give examples of three decisions supported by the Maintenix system. What information do the Maintenix modules provide to support each of these decisions? Answer: 1. What problems does Air Canada hope that Maintenix will solve? The Air Canada hope that the Maintenix will solve the problem that the system werenââ¬â¢t able to interact with one another or with finance and inventory systems. The Air Canada hope that the solution will provide additional functionalities to Air Canadas Engineering, Planning, Materials Management, Line Maintenance and Technical Records departments and is expected to be fully implemented at all Air Canada locations by 2010. 2. How does Maintenix improve operational efficiency and decision-making? Ma tintenix provides a system platform that is accessible via the Web and easy to deploy to all stations around the world. About operational efficiency :Mxi claims that their software reduces repetitive tasks and time chasing missing or incomplete information by allowing maintenance, engineering, and finance divisions to easily share information. The Mxi Maintenix(R) software uses a modern architecture and provides advanced capabilities such as a role-based Web browser interface, automated workflow, integration adapters, electronic signatures, and support for portable wireless devices. In addition to supplying Maintenix, Mxi provides a full range of services including Maintenix implementation, business consulting, systems integration, training, and support. 3. Give examples of three decisions supported by the Maintenix system. What information do the Maintenix modules provide to support each of these decisions? maintenance engineering, line maintenance, and materials management modules. Examples1, the maintenance engineering module: the airline can set up a ââ¬Å"logical onfigurationâ⬠, which describes aircraft components, part relationships, and compatibility rules. The Mix modules used to establish the configuration hierarchy, rules, and maintenance program that all of the other modules depend upon. Examples2, the line maintenance: this module allows Air Canada to ensure that qualified technicians are available before they schedule maintenance. The Mix provides line station planning applications based on the capabilities of the line station facilities as well as the aircraftsââ¬â¢ scheduled locations. Exmaples3, the materials management module: The Mix ensures that minimum amount of each part is always in inventory without causing engineers to be short on parts at any times. When Air Canada technicians work on airplanes, they use several different legacy software packages that have been installed over the last 15 years. The systems donââ¬â¢t always talk to each other or the finance and inventory systems, so the Montreal-based airline has hired Mxi Technologies Ltd. of Ottawa to replace it. The companies announced this week Air Canada is scheduled to start installing Mxiââ¬â¢s Maintenix software next year. The companies did not disclose( ) the total cost, though the contract is worth ââ¬Å"multi millions of dollars,â⬠said Hans Downer, Mxiââ¬â¢s executive vice-president for sales and support. Maintenix is designed to let maintenance, engineering and finance divisions share information, and Mxi claims this reduces repetitive tasks. ââ¬Å"One of the benefits of the Mxi product is, all of this is integrated into a single system, gives us a single view and a single planning mechanism for our entire fleet,â⬠said Steve Bogie, Air Canadaââ¬â¢s program director for the software implementation. It gets us off that legacy platform and puts us on to a Web platform that we can deploy to all of our stations around the world. â⬠Maintenix uses ââ¬Å"n-tierâ⬠architecture that separates the business logic part from the database and from the user interface. From ComputerWorld Canada Kronos wins another Air Canada contract It has integration adapters, which are sold separa tely and lets the software share information with enterprise resource planning (ERP) software, plus flight operations applications, general ledger, supply chain optimization nd human resources systems. It includes workflow functions and can be supported by a third-party application service provider. Air Canada plans to hire a company to host its implementation, though it has not chosen a provider, Bogie said. Its six modules are maintenance engineering, line maintenance, heavy maintenance, shop maintenance, materials management and finance. Air Canada is using all six modules, though the heavy maintenance, shop maintenance and finance modules will only be implemented partially. This is because a separate contractor, Air Canada Technical Services (ACTS), also maintains Air Canada planes. ACTS has been spun off as a separate company and is not a subsidiary, said the airlineââ¬â¢s media relations manager, John Reber. Bogie said Air Canada plans to implement the full set of maintenance engineering, line maintenance and materials management modules. The maintenance engineering module is used to establish rules and users can pre-populate the data. They can also set up a ââ¬Å"logical configuration,â⬠which describes the aircraft components, part relationships and compatibility rules.
Thursday, February 27, 2020
Major Issues and The Place of Traditional Religion Essay
Major Issues and The Place of Traditional Religion - Essay Example n has mostly been undertaken by foreign observers who unfortunately have been less analytical due to their lack of knowledge of African languages, which are normally rich in cultural expression and linguistic (Olupona, 1991). Olupona examines the reasons that made the study of African religion study to suffer serious setbacks in the initial efforts by scholars to get a unit of study from it. According to Olupona, the impact of Christianity and particularly its emphasis of particularity did much damage to the overall study of the African traditional religion and the rightful recognition of its experience. This is essentially what has contributed to the many difficulties bedeviling the study of Africa religion to date, among them being the problem of sources and what could be referred as the goal of Africa religion study. Other problems that have been besetting this study that Olupona has pointed is the size of the Africa as a continent and derogatory appellations like ââ¬Å"dark continent, not to mention the multitude and complexity of each and every quality of Africaââ¬â¢s various language, climate, culture and such like. Another issue that Olupona has examined in depth in this chapter is the problem of the consequences of the European settlements that have wiped out whole cultures and obliterated lots and lots of racial memories, consequently establishing what has been referred to as ââ¬Å"a bit of whitenessâ⬠syndrome in the African continent. He also explores the unrepairable blow that has been caused to the Africa traditional religion by the western education, mercantile or civil services crisscrossing the Africa continent (Olupona, 1991). In this chapter Olupona look at the effect of traditional religion to todayââ¬â¢s South Africa. According to him it is difficult to talk of a single world view in Africa because of the cultural heterogeneity that predominate Africa. He proceeds to interrogate the issue of whether worldview can be differentiated in the late 20th
Tuesday, February 11, 2020
The Utilization of Incretin Mimetics and DPPIV Inhibitors in the Essay
The Utilization of Incretin Mimetics and DPPIV Inhibitors in the Management of Type II Diabetes Mellitus - Essay Example The initial results obtained from clinical trials with these new agents indicate a very high promise of achieving better blood glucose control by adding them to the therapeutic arsenal for the management of type 2 diabetes mellitus. Incretin mimetics are a new class of antidiabetic agents with multiple blood sugar lowering actions that mimic the actions of incretin hormones. Incretins are peptide hormones that originate in the gastrointestinal tract. The two major incretins in humans are glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). These hormones are released during nutrient absorption, when they serve to potentiate the secretion of insulin(Nielsen) Although both GLP-1 and GIP act as incretin hormones in normal subjects, only GLP-1 can be used to treat DM2 because diabetes is often associated with a blunted or absent response to GIP. It has been shown that whereas GLP-1 levels are significantly decreased in DM2, GIP values are normal, suggesting that DM2 patients are resistant to the biological effects of GIP, rendering it relatively ineffective (2A)In mammals, GLP-1 is derived from the proglucagon peptide in mucosal L-cells of the small intestine(Drucker "Glucagon-Like Peptides") D Dipeptidyl peptidase (DPP-IV) extends the bioavailability of many peptides by suppressing their break-down. Several incretin mimetics and DPP-IV inhibitors are undergoing late-stage clinical trials for the treatment of type 2 diabetes and results so far have shown some promises. Their mechanisms of action include enhancement of glucose-dependent insulin secretion; suppression of inappropriately elevated glucagon secretion; slowing of gastric emptying; and appetite suppression(Nielsen). Type 2 diabetes is characterized by the emergence of postprandial (post meal) and, subsequently, fasting hyperglycemia (fasting plasma glucose >125 mg/dl) (Nielsen; Drucker "Glucagon-Like Peptides"). Hyperglycemia results from pancreatic -cells secreting inadequate insulin to compensate for insulin-resistance in peripheral tissues(Porte and Sherwin; Weyer). Only about 33 percent of type 2 diabetes mellitus patients in the United States are able to achieve the 7% HbA1c recommended by the American Diabetes Association. However, after the administration of incretin mimetics and DPP-IV inhibitors on some of these patients, there is a significant improvement in their glycemic profile. Their after-meal blood glucose level, and subsequently their HbA1c were better(Freeman). Despite exercise, diet control and some pharmacological intervention in patients with DM 2, control of blood sugar has become increasingly difficult, especially in patients who had been on long term therapy. The progressive deterioration of the beta-cells of the pancreas, which in turn causes deficient insulin (as well as increased glucagon production) is responsible for this failure of treatment. The incretin mimetics and DPP IV inhibitors are thought to offer hope in improving the glycemic profile of patients because they act primarily to both increase
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